Cannabis analitics

Date: 02.11.2018

''The benefit is - provided that it’s done properly - you’re comparing to a known standard and you can achieve extremely high accuracy and precision.''

Processing of cannabis often involves testing for its potency and other attributes for regulatory requirements and customer information processing. The attributes of the sample may be critical to the quality of the final product. Conventional methods for analyzing the products, such as removing a sample from a grow or production process, sending the sample to a testing facility remote from the production operations, and waiting for the sample analysis results, tend to be time consuming, invasive, and cumbersome. These techniques also tend to delay or disrupt operations. In addition, the conventional methods may be susceptible to sampling and processing errors and as such may not be reliably reproducible. Further, destruction of the sample after testing is often necessary, causing waste and disposal issues.

Potency testing usually happens in an accredited third-party lab, using high-performance liquid chromatography (HPLC) or gas chromatography (GC). The lab will divide a sample of cannabis bud or concentrate, dissolve it in a solvent, dilute it, heat it and pass it through separation columns and then into a detector. It is then compared to known chemical standards to measure potency. The process requires a qualified chemist to ensure that all factors are handled properly. The benefit is - provided that it’s done properly - you’re comparing to a known standard and you can achieve extremely high accuracy and precision. However, each lab has its own methods, which they consider intellectual property. Different labs may get different results based on their processes. State regulatory bodies, such as California’s Bureau of Cannabis Control, have refined rules to achieve consistency between labs, and the International Organization for Standardization (ISO) has standards that are used to vet and qualify methods used at labs. Each lab also has an accreditation agency that audits their methods and chemists. Working tightly with your lab as well as having in-house testing can help ensure that tests are both representative, and that everything is running smoothly on a day-to-day basis to minimize any changes in product output.

Our solution to this issue is based off of spectroscopy, which is simply how matter interacts with radiation. In our case, near-infrared (NIR) light. NIR spectroscopy has been used in the manufacturing industry for decades, permitting manufacturers better control over the quality of their products. It has been used for over 50 years in the agricultural industry, and pharmaceutical corporations have been using the technique, with the approval of the FDA, to monitor metrics like active product ingredient in medicines.

NIR light – that region just beyond the red light that our eyes can see – has become increasingly popular because it contains a wealth of information and can be measured very quickly. The Beacon and Luminary Profiler use the most information-rich portion of the NIR range (1500 – 1985 nm), where chemical features are significantly more pronounced and immune to unimportant factors like the cannabis strain or color.

The use of light as an analytical tool affords a number of distinct advantages over alternative methods, such as GC or HPLC. Because light is non-intrusive to the process, spectroscopy-based measurements require no toxic chemicals for sample prep or analysis, leaving the sample intact for future use.

Spectroscopy-based measurements save time, money and resources, as well as limit potential variation that can arise from extensive sample handling and processing in chromatography methods. Ultimately, this means fast, repeatable and accurate data collection every time.

I.CANNA.BLOG

David Neubauer, M.D., Ph.D., Professor, Co-authors: Mirjana Perkovič-Benedik, Ph.D., Assist., Damjan Osredkar, Ph.D., Assist. Prof. What is new in treatment of children with medicinal cannabis? JANUARY 2019
Alexander Makowski, Ph.D. Cannabis analitics NOVEMBER 2018